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Home Type Curated

10 Things to Know About DNA and RNA Vaccines for Livestock

by The Sharp Edge
September 27, 2023
in Curated, Opinions
Cow Vaccine
  • Not all genetic technologies used in veterinary medicine fall under the categories of “mRNA vaccines” or “mRNA gene therapies.” There are other terms to look out
  • There are several DNA and RNA-based genetic technologies that have received USDA approval or conditional approval for use on chickens, cows, fish, and pigs
  • The required labeling for meat, dairy and egg products is not transparent about possible exposure to DNA or RNA-based veterinary biologics

1. What Are the Different Terms Used for DNA or RNA-Based Veterinary Biologics?

Not all genetic technologies used in veterinary medicine fall under the categories of “mRNA vaccines” or “mRNA gene therapies.” There are other terms to look out for when it comes to genetic technologies for veterinary medicine. These terms also include:

  • “RNA Particle Technology”
  • “RNA Particle Platform”
  • “DNA Vaccine”
  • “DNA Immunostimulant”
  • “Prescription Platform Product”

2. How Do DNA or RNA-Based Veterinary Biologics Work?

With SEQUIVITY’s RNA Particle Technology, a “gene of interest provides instructions” to the immune cells which “translate the sequence into proteins” that “act as antigens.” This triggers an immune response.

As for AgriLab’s ExactVac DNA technology, “the vaccine is produced by splicing a gene for a specific antigen” into “a bacterial plasmid” which “is then multiplied, purified and administered” for “delivery into target cells, where antigens produced by the plasmid elicit an immune response.”

Bayer’s Zelnate DNA immunostimulant is “made up of a special type of immunostimulatory DNA surrounded by a lipid carrier or liposome” which is then “engulfed by the animal’s immune cell” where the “liposome breaks down exposing the DNA” and the “pathogen-associated molecular pattern” of the DNA “attaches to the immune cell’s toll-like receptors triggering activation of the immune cell.”

3. Which Agency Approves Veterinary Biologics?

The USDA’s Animal and Plant Health Inspection Service (APHIS) and their Center for Veterinary Biologics is responsible for approving veterinary biological products including vaccines and DNA or RNA-based biologics. Here are the lists of the currently licensed veterinary biological products and biologics for aquatic animals.

4. Which DNA or RNA-Based Biologics Have Been Approved for Food Animals?

There are several DNA and RNA-based genetic technologies that have received USDA approval or conditional approval for use on chickens, cows, fish, and pigs as outlined below.

  • Chickens

◦In September 2015, Harrisvaccines received a USDA conditional license for an RNA-based avian influenza vaccine. Harrisvaccines “employs their unique SirraVaxSM RNA Particle (RP) technology platform” which can be updated to match current and future avian flu strains.

In October 2015, Harrisvaccines was awarded a USDA stockpile contract of 48 million doses of their “pioneering RNA particle vaccine.” In November 2015, Merck acquired Harrisvaccines.

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◦In November 2017, AgriLabs received USDA conditional approval for “the first DNA vaccine ever licensed for chickens” for avian flu using “AgriLabs’ ExactVac DNA technology with ENABL adjuvant.” In January 2018, Huvepharma acquired AgriLabs. Huvepharma’s DNA-based avian influenza vaccine has a conditional license on APHIS’s most recent list of approved veterinary biological products.

  • Cows

◦Bayer’s Zelnate DNA Immunostimulant received USDA approval for use against bovine respiratory disease (BRD) in January 2014. Zelnate is the “first-of-its-kind” DNA immunostimulant that is a genetic technology rather than a vaccine or antibiotic. Bayer’s DNA immunostimulant is on APHIS’s most recent list of approved veterinary biological products.

  • Fish

◦Elanco’s Apex IHN DNA vaccine for salmonids against Infectious Hematopoietic Necrosis Virus (IHNV) has received USDA approval and is on APHIS’s most recent list of licensed biologics for aquatic animals.

Elanco’s DNA technology uses “relevant genetic components of the virus” that are inserted into a plasmid and injected into the muscle, after which the plasmid “instructs cells to produce antigens, which initiate an immune response.”

  • Pigs

◦In June 2014, Harrisvaccines became the first in the nation to receive USDA conditional licensing for their RNA-based PEDv vaccine for pigs. In November 2015, Merck acquired Harrisvaccines. Merck’s “RNA particle platform” for Coronavirus and Porcine Epidemic Diarrhea Vaccine (PEDv) has conditional approval by the USDA and this product has conditional licensing on APHIS’s most recent list of veterinary biological products.

◦In December 2017, AgriLabs received USDA approval for a DNA-based swine flu vaccine. In January 2018, Huvepharma acquired AgriLabs. Huvepharma’s ExactVac DNA-based swine flu vaccine is on APHIS’s most recent list of approved veterinary biological products.

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◦In 2020, Huvepharma’s DNA-based vaccine platform for pigs received USDA approval as a “prescription platform product” so that the “manufacturer may update the gene insert in this vaccine under expedited procedures to respond to emerging needs.” Huvepharma’s DNA-based swine vaccine platform has conditional licensing as a prescription product on APHIS’s most recent list of approved veterinary biological products.

◦In 2020 and 2021, Merck’s Sequivity RNA vaccines for strains of swine influenza, which use “RNA particle technology,” were approved by the USDA and are on APHIS’s most recent list of approved veterinary biological products.

◦Also in 2021, Merck’s RNA particle technology, for use as a “prescription platform product,” was conditionally approved by the USDA and has conditional licensing on APHIS’s most recent list of veterinary biological products.

5. Is There Ongoing Research Into DNA or RNA-Based Veterinary Biologics?

There are a number of ongoing studies on DNA and RNA-based genetic technologies for veterinary medicine, as outlined below.

  • Bayer Partners with BioNTech to Develop mRNA Vaccines, Drugs for Animal Health, May 2016
  • Development of a Self-amplifying mRNA Vaccine for African Swine Fever and Classical Swine Fever, Start Date: Jun 1, 2021, End Date: May 31, 2024
  • Development of mRNA-based Vaccines for Heterosubtypic Protection Against Infectious Bronchitis and Infectious Laryngotracheitis Viruses, Start Date: Oct 1, 2021, End Date: Sep 30, 2023
  • mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases, February 2022
  • Novel mRNA Vaccine Technology for Prevention of Bovine Respiratory Syncytial Virus, Start Date Oct 1, 2021, End Date Sep 30, 2026
  • Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines, April 2021
  • Vaccines to Reduce Salmonella Infantis in Chickens, Start Date: Sep 1, 2022, End Date: Oct 1, 2024

6. Is It Possible for mRNA Vaccines in Livestock to Contaminate Meat, Dairy or Egg Products?

According to a recent Epoch Times report, a 2014 USDA presentation on Vaccination for Contagious Diseases states that food animals receiving vaccines are subject to “mandatory withdrawal periods prior to slaughter for human consumption. Animals may not be sent to market until the withdrawal time has elapsed.

During the mandatory withdrawal time vaccinated animals or products from vaccinated animals may not enter the food chain. The withdrawal time is determined by the country in which the vaccine is licensed and stated in the product license.” As the Epoch Times report notes, the USDA recognizes that there must be a waiting time between vaccination and slaughter for human consumption due to risks of contaminating the food supply.

The USDA presentation does not, however, acknowledge DNA or RNA-based biologics, but the same standard of waiting times likely applies, as evidenced by Merck’s RNA vaccine for pigs, which states “Do not vaccinate within 21 days before slaughter.” However, Dr. Peter McCullough notes that mRNA technology “is far more durable than we ever could’ve imagined. It lasts in the human body for months unchanged.”

Therefore, even with standard wait times, Dr. McCullough believes it is conceivable that mRNA technology administered to food animals could contaminate the food supply. With that said, the Epoch Times report found “zero peer-reviewed studies looking into the transmissibility of mRNA vaccines from livestock to humans via either milk or meat.”

Dr. Peter McCullough has warned that developers of novel vaccine technologies for veterinary medicine are “blinded with infatuation for molecular biology and have lost sight of biological product safety in the food supply” adding that they have failed to acknowledge the “possibility of collateral impact to humans.”

In addition, Dr. McCullough has raised concerns regarding transmissibility based on a recent study which loaded cow’s milk with mRNA, and by consuming the milk, mice were successfully administered a Covid vaccine.

Dr. McCullough points out the “considerable ethical issues” this research presents, with a large segment of the public having “strong objections to mRNA in the food supply, particularly if it was done surreptitiously or with minimal labelling/warnings.”

7. Are There Labeling Requirements for Meats, Dairy or Eggs That May Have Been Contaminated by DNA or RNA-Based Veterinary Biologics?

The required labeling for meat, dairy and egg products is not transparent about possible exposure to DNA or RNA-based veterinary biologics. The USDA does, however, require “Bioengineered” labeling for foods that “contain detectable genetic material that has been modified through certain lab techniques and cannot be created through conventional breeding or found in nature.”

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It is unclear whether the USDA’s testing process for “detectable genetic material” is capable of picking up traces of genetic material from biologics used in veterinary medicine.

Moreover, the USDA’s “Organic” labeling does appear to permit vaccines for livestock used for meat, dairy and eggs, though the requirements state that animals must not be given hormones or antibiotics. A 2013 Agricultural Marketing Service document states that “organic livestock must be: – Produced without genetic engineering.” However, the same document goes on to say that “Only a few drugs, such as vaccines, are allowed” for organically raised livestock.

Furthermore, in many cases, labeling is not clear about the country from which meats originate. Country of Origin Labeling (COOL) requirements were dropped for beef and pork in 2016. COOL requirements remain in place for lamb, goat, chicken, and fish. Additionally, USDA regulations on meat, poultry and eggs have enabled “Product of USA” labeling for animals born and raised in other countries and only processed in the U.S.

However, in March 2023, the USDA proposed a new rule to restrict labeling for “Product of USA” or “Made in the USA” to be used on “meat, poultry and egg products only when they are derived from animals born, raised, slaughtered and processed in the United States.”

8. Which Organizations Are Behind This Agenda?

According to a Corey’s Digs report, Codex Alimentarius was established by the UN’s Food and Agriculture Organization (FAO) and the WHO, for “the sole purpose of setting the standards and guidelines for all food that is consumed by human beings.”

The report states that Codex does not have the authority to make laws, “so the 189 country members, 20 of which are heads of the various committees, take these ‘standards’ and create regulations and laws in their respective country. The USDA, for example, is a driving force for not only adhering to the standards, but making certain other countries follow in lock step as well.”

Codex Alimentarius plays “a key role” in the implementation of new technologies within food standards, including “genetic editing” and “nanotechnology applications in the food sector” as well as “alternative food proteins.”

9. What Are Lawmakers, Producers and Concerned Citizens Doing to Protect Against Contamination of the Food Supply From mRNA Vaccines?

Lawmakers have proposed legislation in Arizona, Idaho, Missouri, South Carolina, Tennessee, and Texas to prohibit mRNA in meats or to require disclosure in food labeling. While legislation in Missouri and Idaho failed, efforts to block mRNA vaccines in livestock remain ongoing in other states.

A trade group, known as The Beef Initiative, has pledged that their Beef Box producers will not “use any mRNA vaccines in their livestock.” Over 100 producers are partnered with The Beef Initiative and can be found here.

Attorney Tom Renz has spearheaded the movement by states for transparency and disclosure of mRNA gene therapies in the food supply. Renz helped to draft Missouri’s HB1169. Naomi Wolf of Daily Clout is also promoting the cause. Doctor Peter McCullough has raised awareness on the issue of genetic technologies used in veterinary medicine and the potential dangers to the food supply in recent interviews and on substack publications.

10. What Can the Public Do about It?

Stay informed and inform others by sharing this information. Additional resources on this topic are listed below. Support lawmakers and advocacy groups pushing for transparency and blocking DNA or RNA-based biologics from entering the food supply. Know what’s in your food and who is producing it.

Buy from producers that have pledged to never use DNA or RNA-based genetic technologies, such as The Beef Initiative. Corey’s Digs has also published an excellent resource for finding high-quality foods as well as an incredible source for US Prime and High Choice Beef.

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Antidote





Two Storms, One Harvest

Empty Shelves

Every food crisis in living memory has been a one-shock event. The 2008 price spike was a commodity bubble. The 2020 shortages were a logistics failure. The 2022 grain scare was a war on one exporter’s ports. Each time, the system bent, adjusted, and recovered, and each time the experts assured us afterward that global markets are simply too big and too diversified to fail.

What nobody in Washington seems eager to discuss is that 2026 is shaping up to be something the modern food system has never actually faced. Two independent shocks, one climatic and one geopolitical, are converging on the same harvest cycle at the same time. Not sequentially. Simultaneously.

Start with the weather. The Pacific Ocean is currently building toward what forecasters now openly call a record event. NOAA’s Climate Prediction Center puts the odds of at least a strong El Niño near 88 percent, with roughly two in three odds it reaches “very strong” status, the tier reserved for perhaps three or four events in the entire satellite era. Every major global model now projects a median peak in Super El Niño territory, and most of them project it exceeding the 2015-16 event, which until now held the modern record. Sea surface anomalies were already brushing the super threshold in mid-July, months before these events normally peak. The atmosphere has already shifted into El Niño mode, and the event is forecast to crest in late fall and early winter.

This is not about “climate change.” It’s about the standard cycles of weather, and the cycle we’re currently in is one that has likely devastated societies in the past. We’re better prepared as a society today, but not all Americans are equally prepared.

Serious households have started doing the quiet math on their own. Grocery bills tell part of the story, and the forecast maps tell the rest, which is why long-term food storage has moved from fringe hobby to mainstream line item in the family budget, with established suppliers like Heaven’s Harvest seeing demand from people who five years ago would have rolled their eyes at the idea. That instinct is not paranoia. It is pattern recognition, and the pattern is worth walking through carefully.

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The Fertilizer Clock Is Already Running

While the Pacific warms, the second shock has been unfolding in the Strait of Hormuz. The conflict with Iran turned the world’s most important energy chokepoint into a contested waterway, and the consequences reach far beyond the gas pump. Roughly a third of global fertilizer trade moves through Hormuz, and the disruption sent urea prices up 86 percent year over year by March, with a 53 percent jump in a single month.

The World Bank projects energy prices rising about 24 percent in 2026 and fertilizer about 31 percent. By its own accounting, fertilizer prices ran 35 percent higher in the first five months of this year than the same period last year.

Here is the mechanism the nightly news will not explain. Fertilizer is not a grocery item. It is a time-delayed input. The nitrogen a farmer in Iowa or Punjab could not afford to apply this spring does not show up as a problem this spring. It shows up as a thinner harvest six to twelve months later.

The World Bank’s own food security brief concedes that the effects of reduced applications earlier this season “are likely to become visible only later in harvest outcomes.” Translate that from institutional language into plain English and it means this. The damage is already done, it is already in the ground, and we are simply waiting for it to arrive on the shelf.

Now check the calendar. Six to twelve months from the spring planting season lands us squarely in late 2026 and early 2027. Which is precisely when the strongest El Niño in the instrumental record is forecast to peak, bringing its signature droughts to Southeast Asia, Australia, southern Africa, northern Brazil, and South Asia, the very regions that grow the world’s rice, sugar, and oilseeds.

The World Bank warns openly that a strong El Niño “could disrupt multiple crop belts simultaneously” on top of the conflict-driven input costs. Their baseline projection assumes the Middle East disruptions ease by autumn. What in the last two years of Middle East history suggests that assumption is safe?

The System Has No Slack Left

The comfortable answer is that global markets always adjust. But adjustment requires slack, and the slack is gone. Global cereal production is expected to decline from last year’s records even before El Niño does its work. The UN World Food Programme, hardly a den of right-wing preppers, is calling this the most significant disruption to its supply chains since Covid and the invasion of Ukraine, and its supply chain director put the stakes bluntly.

Today’s supply chain challenges are tomorrow’s hunger crisis.

There is also a political dimension that markets cannot price. When food gets scarce, governments do not behave like economists. They behave like politicians. Export bans, hoarding mandates, and panic buying at the national level turned the modest rice shortfall of 2008 into a global crisis, and analysts are already warning that import-dependent nations are the first dominoes.

The 2015-16 Super El Niño, a far weaker event than what is now forecast, threw tens of millions into food stress across Africa and Asia. This one is projected to be stronger, and it arrives with fertilizer already rationed by price and shipping lanes already contested by missiles.

What Joseph Knew

Scripture does not treat preparation for lean years as faithlessness. It treats it as wisdom delivered in advance to those willing to act on it.

Behold, there come seven years of great plenty throughout all the land of Egypt: And there shall arise after them seven years of famine; and all the plenty shall be forgotten in the land of Egypt.

Joseph did not respond to that warning with a hashtag or a committee. He stored grain during the years of abundance, and when the famine came, Egypt stood while its neighbors begged. The lesson is not that famine is certain. It is that the time to prepare is precisely when preparation still looks optional.

Nobody who filled a pantry in a year of plenty has ever regretted it, and nobody standing in an empty aisle has ever been glad he waited for certainty.

None of this calls for panic, and panic is the enemy of sound judgment anyway. It calls for the same unglamorous prudence our grandparents considered ordinary. Keep some cash margin, know your local growers, and put real food in deep storage while it is cheap and available, because the entire arc of this story is that cheap and available is a closing window.

Families looking for a straightforward place to start can visit Heaven’s Harvest and use promo code Patriot for 15 percent off long-term storable food. The forecasts may yet soften, the strait may yet reopen, and we should pray they do. But hope is a fine thing to hold and a foolish thing to eat.

Tags: BeefDNAFoodLedeLivestockmeatmRNAThe Sharp EdgeTop Story
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